| Sébastien Leblanc - Founder | Initial donor of the hospital in 1641. |
| François Simonnet de Coulmiers - Director (1804) | Impose brutal and innovative methods. |
| Jean-Étienne Esquirol - Chief Medical Officer | Inspired reconstruction and psychiatric theories. |
| Émile Jacques Gilbert - Architect | Designed the neoclassical building (1838-1886). |
| Marquis de Sade - Famous intern | Closed from 1803 until his death in 1814. |
| Paul Verlaine - Famous intern | Several stays between 1887 and 1890. |
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