| François de Luxembourg - Duke of Piney | First noble owner in 1570. |
| Marie de Médicis - Regent of France | Buyer of the estate in 1612. |
| Cardinal de Richelieu - Minister of Louis XIII | Owner in 1627, uses a secret passage. |
| Germain Boffrand - Architect | Enlarged the hotel between 1709 and 1716. |
| Emmanuel Joseph Sieyès - Director under the Executive Board | Prepare the coup d'état of the 18 mist. |
| Napoléon Bonaparte - First Consul | He lived there in 1799 after the coup d'état. |
| Gérard Larcher - President of the Senate | Presently occupied since 2014. |