| Nicolas Colbert - Bishop of Auxerre | Founded the General Hospital in 1675. |
| Jacques-Henri Girard de Cailleux - Medical Director | Designed asylum according to the principles of Esquirol. |
| Baron Haussmann - Prefect of Yonne (1850-1852) | Permitted completion of work in 1858. |
| Jean Boivin - Departmental architect | Directed the construction of the pavilions. |
| Pierre Scherrer - Chief Medical Officer (1942-1975) | Testimony of conditions under occupation. |
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