| Daniel-Charles Trudaine - Founder | Created school in 1747. |
| Jean-Rodolphe Perronet - First Director (1747–94) | Father of the formation of engineers. |
| Henri Navier - Former student and teacher | Pioneer of fluid mechanics. |
| Gaspard-Gustave Coriolis - Teacher and scientist | Discoverer of Coriolis' strength. |
| Eugène Freyssinet - Former student | Inventor of prestressed concrete. |
| Sadi Carnot - Former student | President of the Republic (1887–94). |
| Élisabeth Borne - Former student | Prime Minister (2022–2024). |