| François-Alexandre Duquesney - Architect | Designer of the original station (1847-1849). |
| Pierre Cabanel de Sermet - Engineer | Co-author of the initial project and defender of a separate station. |
| Louis-Napoléon Bonaparte - President (future Napoleon III) | Inaugurated the station in 1850. |
| Henri Lemaire - Sculptor | Author of the allegorical statue of Strasbourg (West Front). |
| Henri Varenne - Sculptor | Created the statue of Verdun (eastern border) and the allegories Marne/Meuse. |
| Jules Bernaut - Chief Architect | Directed symmetrical enlargement (1926-1931). |
| Albert Herter - American Painter | Author of *Departure of the hair* (1926), monumental fresco. |