| Claude Le Ragois de Bretonvilliers - Sponsor and owner | Secretary to King Louis XIII. |
| Jean Androuet du Cerceau - Architect | Initial designer of the hotel. |
| Pierre Le Muet - Architect | Finished the building. |
| Simon Vouet - Painter-Decorator | Decorated the hotel in 1643. |
| Sébastien Bourdon - Painter | Orna la Grande Galerie. |
| Marie Accarie - Owner and patron | Embellished the hotel after 1645. |
| Antoine Lavoisier - Member of the Farm Committee | Worked in the hotel. |
| Pierre Samuel Du Pont de Nemours - Revolutionary tenant | Used printing in 1791. |
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