| Antoine Perrenot de Granvelle - Cardinal and sponsor | Initiator of construction in 1581. |
| Richard Maire - Bisontin architect | Initial designer, died in 1585. |
| Jean Maire - Successor architect | Son of Richard, take over the yard. |
| Thomas-François d’Oiselay - Heir of the Cardinal | Sell the hotel in Besançon in 1618. |
| Jacques Henri de Durfort - First resident governor | Busy hotel from 1677. |
| Jean-Baptiste de Durfort - Duke of Duras | Responsible for enlargements in 1734. |
| Alphonse Delacroix - 19th century architect | Reconstructed the left wing in 1840. |
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