| Henri Gagnon - Doctor and notable Grenoblois | Initiator of the Natural History Cabinet. |
| Étienne Ducros - First Custody of the Cabinet (1775-1807) | Responsible for the first collections. |
| Dominique Villars - Dauphinist botanist | Author of a herbarium acquired by the museum. |
| Jacques-Joseph Champollion-Figeac - Conservator and brother of Jean-François Champollion | Directs the Cabinet from 1808 to 1816. |
| Albin Crépu - Cabinet Guard and then Professor | Acquiert the herbarium of Villars in 1825. |
| Paul Benoît Barillon - Municipal architect | Designs the current building (1849-1855). |
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