| Charles André - Founder and first director | Selected the site of Saint-Genis-Laval in 1877. |
| François Gonnessiat - Astronome and Discoverer | Confiscates the oscillations of the Earth's axis (1894). |
| Marie Bloch - Astronomy and Researcher | Prix Lalande 1960, spectroscopy specialist. |
| Jean Dufay - Director (1933-1966) | Modernized the observatory towards astrophysical. |
| Agop Terzan - Astronome and Discoverer | Identified thousands of celestial objects. |
| Hélène Courtois - Contemporary Astrophysician | Co-discovery of the Laniakea superamas. |
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