| Louise Labé - Poetess and student | Figure of the School of Lyon, studied at the college. |
| Étienne Martellange - Jesuit architect | Designed the chapel of the Trinity. |
| Jean de Saint-Bonnet - Founder of the Observatory | Created the first observatory in Lyon. |
| Laurent Béraud - Astronome and Director | Directed the observatory from 1740 to 1762. |
| André-Marie Ampère - Epoonymic physician | The high school had its name since 1888. |
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