| Jean-Baptiste Colbert - Minister of Louis XIV | Initiator of modern construction. |
| Nicolas Arnoul - Intendant of galleys (1665–1774) | Supervised the three extension phases. |
| Niquet et André Boyer - Engineer and architect of the King | The third phase (1685–90) was designed. |
| François Chabert - Occupational surgeon (1689–1724) | Author of published medical observations. |
| Antoine Moulinneuf - Surgeon and specialist in hydropisia | Death in the plague of 1720. |
| Pierre-Victor Malouet - Navy Officer (1781) | Organized the sale of the arsenal to the city. |
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