| Étienne le Loup - Counsellor for Louis XI | Builder of the mansion in 1471. |
| Charles VIII - King of France | Buyer and transformer in royal residence. |
| Anne de Bretagne - Queen of France | Beneficiary of the castle. |
| Léonard de Vinci - Artist and inventor | There lived and died (1516-1519). |
| François Ier - King of France | Offered the Clos Lucé to Leonard. |
| Francesco Melzi - Disciple of Leonard | Heir of his manuscripts in 1519. |
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