| Abraham Hirsch - Architect | Designer of the synagogue, neo-Byzantine style. |
| Napoléon III - Emperor | Created the regional Consistory in 1857. |
| Joseph Kuppenheim - President of the Consistory (1862) | Proposed a temporary place of worship. |
| Bernard Schonberg - Grand Rabbi of Lyon | Arrested in 1943, deported to Auschwitz. |
| David Feuerwerker - Grand Rabbi (1944-1946) | Abolite the organ during Shabbat. |
| Nissim Malka - Current Rabbi (since 2015) | Leads the synagogue today. |
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