| Saint Lizier - Bishop of the 6th century | Patron of the village, canonized after his participation in the Council of Agde. |
| Antoine Favier - Toulouse goldsmith | Author of the reliquary bust of Saint Lizier (1531). |
| Bernard Coignet de Marmiesse - 17th century bishop | Initiator of the bishop's palace. |
| Jean-Michel Wilmotte - Contemporary architect | Renovation of the Palace of Bishops in the 21st century. |
| Alexandre Grothendieck - Mathematician | Died at the CHAC de Saint-Lizier in 2014. |