| Charles VIII - King of France (1483–1498) | Sponsor of early Renaissance works. |
| Louis XII - King of France (1498–1515) | Added a Renaissance wing to the castle. |
| François Ier - King of France (1515–1547) | Invita Leonardo da Vinci at Clos Lucé. |
| Léonard de Vinci - Artist and inventor | Dead in Amboise, buried in the chapel. |
| Abd el-Kader - Amir Algerian | Prisoner at the castle (1848–52). |
| Louis-Philippe - King of the French (1830–48) | Partial restoration of the castle in the 19th century. |
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