| Heinrich Philippi - Apothecary and Founder | First occupier known in 1268. |
| Hesso et Hesselin Philippi - Family Successors | Apothecaries until 1398. |
| Aeneas Sylvius Piccolomini - Resident in 1432 | Living before his papacy (Pius II). |
| Albrecht Wessner - Owner in 1598 | Unify the three buildings. |
| Famille Spielmann - Apothecary Dynasty | Owners in the 17th-18th century. |
| Jacques Reinbold Spielmann - Professor of Medicine | Teaching botany in the 18th century. |
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