| Prince Albert Ier de Monaco - Founder and patron | Initiator of the project, passionate about oceanography. |
| Paul Delefortrie - Museum architect | Designer of the building's neo-baroque plans. |
| Gustave Dussart - Sculptor of facades | Author of the allegories "Le Secours"* and "Le Progrès"*. |
| Commandant Jacques-Yves Cousteau - Director (1957-1988) | Reinforced the scientific and pedagogical dimension. |
| Prince Albert II de Monaco - Present Honorary President | Porter of the centennial renovation plan. |
| Robert Calcagno - Director General (since 2009) | Responsible for the modernization of the museum. |