| Jean Dufay - Director (1936–1965) | First Director, also head of the Lyon Observatory |
| Charles Fehrenbach - Director (1966–1983) | Deputy Director since 1943, specialist in astrophysical |
| Michel Mayor et Didier Queloz - Astrophysicists | Discoverers of 51 Pegasi b in 1995 |
| Gérard Mégie - Atmospheric scientist | Pioneer of Lidar telemetry at the OHP in the 1980s |
| Jean Prouvé - Ferronier and architect | Design of the aluminium cover of the large dome |
| Marc Ferrari - Director since 2023 | Specialist in instrumentation and adaptive optics |
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